Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

Identifieur interne : 000295 ( Main/Exploration ); précédent : 000294; suivant : 000296

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Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

Auteurs : Abdo A. Elfiky

Source :

• Life Sciences [ 0024-3205 ] ; 2020.

RBID : PMC:7089605

Descripteurs français

• KwdFr :
  • AMP (), AMP (analogues et dérivés), AMP (métabolisme), Alanine (), Alanine (analogues et dérivés), Alanine (métabolisme), Alignement de séquences, Antiviraux (), Antiviraux (métabolisme), Biologie informatique (), Domaine catalytique, Guanosine monophosphate (), Guanosine monophosphate (analogues et dérivés), Guanosine monophosphate (métabolisme), Guanosine triphosphate (), Guanosine triphosphate (métabolisme), Humains, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Liaison aux protéines, Motifs et domaines d'intéraction protéique, Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Protéines virales (), Protéines virales (antagonistes et inhibiteurs), Protéines virales (métabolisme), RNA replicase (), RNA replicase (antagonistes et inhibiteurs), RNA replicase (métabolisme), Repositionnement des médicaments (), Ribavirine (), Ribavirine (métabolisme), Similitude de séquences d'acides aminés, Simulation de docking moléculaire, Sofosbuvir (), Sofosbuvir (métabolisme), Structure en brin bêta, Structure en hélice alpha, Séquence d'acides aminés, Thermodynamique, Uridine triphosphate (), Uridine triphosphate (métabolisme).
• MESH :
  • analogues et dérivés : AMP, Alanine, Guanosine monophosphate.
  • antagonistes et inhibiteurs : Protéines virales, RNA replicase.
  • métabolisme : AMP, Alanine, Antiviraux, Guanosine monophosphate, Guanosine triphosphate, Protéines virales, RNA replicase, Ribavirine, Sofosbuvir, Uridine triphosphate.
  • traitement médicamenteux : Infections à coronavirus, Pneumopathie virale.
  • virologie : Infections à coronavirus, Pneumopathie virale.
  • AMP, Alanine, Alignement de séquences, Antiviraux, Biologie informatique, Domaine catalytique, Guanosine monophosphate, Guanosine triphosphate, Humains, Liaison aux protéines, Motifs et domaines d'intéraction protéique, Protéines virales, RNA replicase, Repositionnement des médicaments, Ribavirine, Similitude de séquences d'acides aminés, Simulation de docking moléculaire, Sofosbuvir, Structure en brin bêta, Structure en hélice alpha, Séquence d'acides aminés, Thermodynamique, Uridine triphosphate.

English descriptors

• KwdEn :
  • Adenosine Monophosphate (analogs & derivatives), Adenosine Monophosphate (chemistry), Adenosine Monophosphate (metabolism), Alanine (analogs & derivatives), Alanine (chemistry), Alanine (metabolism), Alphacoronavirus (enzymology), Alphacoronavirus (genetics), Amino Acid Sequence, Antiviral Agents (chemistry), Antiviral Agents (metabolism), Betacoronavirus (enzymology), Betacoronavirus (genetics), Catalytic Domain, Computational Biology (methods), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Drug Repositioning (methods), Guanosine Monophosphate (analogs & derivatives), Guanosine Monophosphate (chemistry), Guanosine Monophosphate (metabolism), Guanosine Triphosphate (chemistry), Guanosine Triphosphate (metabolism), Humans, Molecular Docking Simulation, Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology), Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, RNA Replicase (antagonists & inhibitors), RNA Replicase (chemistry), RNA Replicase (metabolism), Ribavirin (chemistry), Ribavirin (metabolism), Sequence Alignment, Sequence Homology, Amino Acid, Sofosbuvir (chemistry), Sofosbuvir (metabolism), Thermodynamics, Uridine Triphosphate (chemistry), Uridine Triphosphate (metabolism), Viral Proteins (antagonists & inhibitors), Viral Proteins (chemistry), Viral Proteins (metabolism).
• MESH :
  • chemical , analogs & derivatives : Adenosine Monophosphate, Alanine, Guanosine Monophosphate.
  • chemical , antagonists & inhibitors : RNA Replicase, Viral Proteins.
  • chemical , chemistry : Adenosine Monophosphate, Alanine, Antiviral Agents, Guanosine Monophosphate, Guanosine Triphosphate, RNA Replicase, Ribavirin, Sofosbuvir, Uridine Triphosphate, Viral Proteins.
  • chemical , metabolism : Adenosine Monophosphate, Alanine, Antiviral Agents, Guanosine Monophosphate, Guanosine Triphosphate, RNA Replicase, Ribavirin, Sofosbuvir, Uridine Triphosphate, Viral Proteins.
  • drug therapy : Coronavirus Infections, Pneumonia, Viral.
  • enzymology : Alphacoronavirus, Betacoronavirus.
  • genetics : Alphacoronavirus, Betacoronavirus.
  • methods : Computational Biology, Drug Repositioning.
  • virology : Coronavirus Infections, Pneumonia, Viral.
  • Amino Acid Sequence, Catalytic Domain, Humans, Molecular Docking Simulation, Protein Binding, Protein Conformation, alpha-Helical, Protein Conformation, beta-Strand, Protein Interaction Domains and Motifs, Sequence Alignment, Sequence Homology, Amino Acid, Thermodynamics.

Abstract

Url:

• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089605

DOI: 10.1016/j.lfs.2020.117477
PubMed: 32119961
PubMed Central: 7089605

Affiliations:

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